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Chronic lymphocytic leukemia (CLL) is really a lymphoid malignancy characterised with the proliferation and accumulation of mature CD5+ B cells while in the blood, bone marrow and lymphoid tissues. The diagnosis of CLL calls for the presence of ≥five x109/L mono - clonal B cells of typical phenotype within the blood.
mutations and sophisticated kar yotype. It follows a linear evolution through the CLL clone in the recurrent acquisition of CDKN2A
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